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Abstract Details

Abstract Title

Association of ACSL4 gene Polymorphisms and Elite Endurance Athletes Performance

Abstract Theme

Genetics and sport

Type Presentation

Oral presentation

Abstract Authors

Presenter Wu JIan - Capital University of Physical Education and Sports (School of Kinesiology and Health) - CN
Zheng Xiaohong - Capital University of Physical Education and Sports (Faculty of Graduate Studies) - CN
HuYang - Beijing Sports University (Beijing Sports University) - CN
Yan Shoufu - Capital University of Physical Education and Sports (School of Kinesiology and Health) - CN
WuHao - Capital University of Physical Education and Sports (Scientific Research Department) - CN

Presentation Details

Room: Venus        Date: 1 September        Time: 17:20:00        Presenter: Jian Wu

Abstract Resume

Background:
Long chain acyl-CoA synthetases (ACSLs) are encoded by a multi-gene family. Synthesis of acyl-CoA catalyzed by acyl-CoA synthetase (ACS) is the first step in mammalian response to the use of fatty
acids, so ACSL in fat metabolism plays a major role. The ACSL family members include five different ACSL isoforms, each encoded by a separate gene and have multiple spliced variants. A finding
findings suggest that the ACSL1 gene polymorphism rs6552828 is marginally associated with male elite endurance status in Chinese (Han) population yet such association was not found in Chinese females.
This research is to explore the association of polymorphisms in ACSL4 gene with the performance of the elite endurance athlete.

Methods:
A total of 122 elite runners and 125 healthy non-athletes in the population of Han nationality from northern China were used in this study. The SNP sites rs5943427 and rs1324805 in the ACSL4 gene were
analyzed with MassArray high-throughput DNA analyzer with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. A series of statistical methods were carried out to
investigate the correlation between the SNP and the elite endurance capacity.

Results:
In male endurance athletes, the frequencies of the GG genotype (P=0.001) and G allele (0.019) in rs5943427 were significantly higher than their controls. The TT genotype (P=0.008) and T allele
(P=0.000) in rs1324805 were significantly higher than controls. The two SNPs GT haplotype is significantly higher than controls (P=0.001). Such associations were not found in female endurance
athletes.

Conclusions:
The gene polymorphisms rs5943427 and rs1324805 in the ACSL4 gene is associated with the performance of elite male endurance athletes in Han population from northern China. Our findings exemplify the
need for further genetic association studies in the field of sport sciences.

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