Background: It is a fact that high altitude training can induce inflammatrory and oxidase stress,which is lead to myocardial damage and dysfunction. The diagnosis of exercise-induced
minor myocardial damage was difficult due to the lack of cardiospecific markers. The aim is to investigate the correlation between the exercise-induced oxidase stress and myocardial damage in high
altitude environment and to find a sensitive marker of inflammatory and oxidative stress associated with myocardial damage for preventing the occurrence of heart diseases caused by high altitude
Methods:30 Subjects (male, age 19.3 ± 4.0 yr, weight: 69.1 ±5.4 kg, BMI: 21.0 ± 1.2 kg/m2, VO2 peak 36.6 ± 6.2 mL•kg-1•min-1)were randomly assigned to altitude training (group A) and
plain training (group P) with a progressively increasing load cycle ergometer for 8 days.Whole blood was taken for the haematological profile after training every day. The inflammatory markers
Cytokine(interleukin-6 (IL-6), Myeloperoxidase (MPO), high sensitivity C reactive protein(hsCRP)) in blood plasma were measured by ELISA.; Cardiac troponin T (cTnT) and N-terminal pro-brain
natriuretic peptide(NTproBNP) were determined using electro chemiluminescence technology employed within the Modular analytics E170 analyzer. The oxidative stress markers malondialdehyde (MDA) and
conjugated dienes (CD) were determined both by High Performance Liquid Chromatography (HPLC) respectively. Polymorphonuclear elastase (PMNelas) was determined using a quantitative enzyme immunoassay.
Plasma creatine kinase (CK) and creatine kinase MB (CKMB) activity was measured using anautomatic analyzer.
Results: MDA and CD as oxidative stress markers increased significantly. Furthermore, IL-6 and hsCRP as components of the APR as well as PMNelas and MPO as markers of the cellular
inflammatory response rose significantly in group A. Cross-Matching regression analysis showed that there was no significant correlation between cTnT and NT-proBNP immediately after high altitude
training in group p. the strong correlation that was observed between these parameters the day after training in group A include the correlation between cTnT or NTproBNP and any parameter reflecting
inflammatory (IL-6, hsCRP, MPO, PMNelas) or oxidative stress (MDA, CD).the Parameters reflecting peripheral muscle stress (CK, CKMB) were positively correlated with cTnT.
Conclusions:It has been demonstrated that training in Plateau environment is associated with an increase in biomarkers for myocardial stress even in healthy trained subjects without
signs for myocardial disease. Increased concentration of the inflammatory markers Cytokine acutely modulate cardiac function may induce cardiomyocyte damage. Therefore, there is a rational background
to study the association between the inflammatory response biomarkers for cardiomyocyte stress. In addition, measuring oxidative stress markers and inflammatory factor may provide further information
for preventing myocardial damage in high altitude training.