Background: Alzheimer’s diseases (AD) etiology and pathogenesis is not very clear. The AD will become the 21st century one of the most serious disease threat to human health. Discuss
how to prevent the happening of the symptoms of AD has important social significance. The paper is to research the impact of aerobic exercise on learning and memory ability of AD mice.
Methods: This paper adopts literature review method, analyzed the AD to earlier research and designed exercise intervention study on AD model mice. Chose 20 healthy male Kunming mice
for the Experiment (weight 18-22g), obtained the Alzheimer's disease model by D-galactose subcutaneous injection, and chose 10 mice in the running the stage for aerobic exercise (ie, AD exercise
group) and the other 10 mice did not exercise (ie, AD quiet group).After 40 days the treadmill aerobic exercise for the AD exercise group mice ,there will be a step-down test for both the AD quiet
group mice and the AD exercise group mice in order to study learning and memorizing behavior.
Results: Several hypothesis of Alzheimer disease (AD) mechanisms, such as A beta cascade theory (theory of amyloid protein), tau phosphorylation doctrine (microtubule protein tau gene
mutation theory), gene mutation theory, acetylcholine neurons damage theory, theory of cytokines, nitric oxide theory, etc. In the learning behavior tests, AD quiet group reaction time significantly
increased than the mice AD exercise group (P <0.05); while the AD quiet group showed a trend of decreasing in error frequency than AD exercise group. In the memory retention test, the incubation of AD
quiet mice were significantly shorter than the AD exercise group (P <0.05); and the number of errors of the very group is more than the AD exercise group, significant difference (P <0.01). This
experiment provides the experimental data for exploring the role of aerobic exercise on the regulation in the development process of Alzheimer's disease.
Conclusions:The results suggest that the early exercise intervention has positive effect to improve AD. The aerobic exercise can improve test scores in learning and memory behavior of
AD exercise model mice.