Background:Vascular endothelial function has been impaired by cardiovascular risk factors, and to be related to an increased incidence of arteriosclerosis and the onset of
cardiovascular disease. Among multiple cardiovascular risk factors, sedentary lifestlye, lipid abnormalities, and estrogen deficiency have central roles in aging association with endothelial
dysfunction. More importantly, endothelial dysfunction can be reversed at the the early stage. With angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism, the deletion variant (DD)
is related to higher levels of circulating angiotensin II than I allele carries (II/ID), and the response to various forms of exercise training may be at least partly dependent on the ACE genotype
polymorphism (I/D). A healthy lifestyle has a deep impact on cardiovascular risk, and regular physical exercise represents the most effective nonpharmacological intervention for the prevention of
cardiovascular disease. We aimed to determine the effect of ACE I/D genotype on the response to resistance training on endothelial functions in Chinese Han postmenopausal women with ACE I/D genotypes.
Methods:Sixty-three (DD=8, II=22, ID=33) sedentary postmenopausal women (mean age, 60± 4y) participated in a 12-week program of resistance training at moderate intensity. Blood total
cholesterol (TC), Low density lipoprotein-cholesterol (LDL-C), High density lipoprotein cholesterol (HDL-C), Triglyceride (TG) and Flow-mediated dilation (FMD) were evaluated before and after
intervention program. ACE genotype was determined using standard methods.
Results:At baseline, the ACE DD genotype showed significantly higher lipids abnormal rate, mainly in LDL-C and TC level and lower FMD than the ACE II/ID individuals. After resistance
training, both subgroups significantly decreased abnormal rates of lipids-plasma levels and FMD (P ＜0.01 or P＜0.05, respectively). Moreover, all the lipids parameters were significantly reduced in the
ACE DD participants (P＜0.01 ), whereas the ACE I-allele carriers showed a little decrease.
Conclusions:ACE I/D polymorphism is linked to different blood fat levels and endothelial function, and ACE DD genotype carriers show vulnerable to endothelial-dependent vasodilation
due to metabolic disorders of lipids. The introduction of resistance training positively influences the menopause lipid metabolism and endothelial function changes, independent of ACE I/D genotype.