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Abstract Details

Abstract Title

Insulin Resistance may Reduce FGF-21 and Adiponectin/leptin Ratio Favoring the Inflammatory State in Obese Adolescents: Long-term Effects of Exercise Training and Multicomponent Therapy

Abstract Theme

Physical activity and health

Type Presentation


Abstract Authors

Raquel Munhoz da Silveira Campos - Federal University of São Paulo (UNIFESP); Federal University of São Carlos (UFSCar) (Post Graduate Program of Nutrition; Department of Physiotherapy, Therapeutic Resources Laboratory.) - BR
Deborah Cristina Landi Masquio - Federal University of São Paulo (UNIFESP) (Post Graduate Program of Nutrition) - BR
Flávia Campos Corgosinho - Federal University of São Paulo (UNIFESP) (Post Graduate Program of Nutrition) - BR
Presenter Ana Claudia Pelissari Kravchychyn - Federal University of São Paulo (UNIFESP) (Post Graduate Program of Nutrition) - BR
Sofia Emanuelle de Castro Ferreira Vicente - Federal University of São Paulo (UNIFESP) (Post Graduate Program of Nutrition) - BR
Lian Tock - Weight Science (Weight Science) - BR
Sergio Tufik - Federal University of São Paulo (UNIFESP) (Psychobiology Department) - BR
Marco Túlio de Mello - Federal University of Minas Gerais (UFMG) (School of Physical Education, Physiotherapy and Occupational Therapy) - BR
Ana Raimunda Dâmaso - Federal University of São Paulo (UNIFESP) (Post Graduate Program of Nutrition) - BR

Presentation Details

Poster Exhibition Site (Local): Yellow - 25        Date: 1 September        Time: 8am to 7pm        Presenter: Ana Claudia Kravchychyn

Abstract Resume

Insulin resistance is a commonly metabolic complication present in obese population. Recently studies proposed that the synergistic effect of fibroblast growth factor-21 (FGF-21) and insulin might be
due to the improvement of insulin sensitivity mediated by this new discovered hormone. The purpose of this study were to investigate the effects of a long weight loss therapy in to differents groups
(with and without Insulin Resistance) of obese adolescents on metabolic profile, biomarkers of inflammation and FGF-21 concentration.

It was involved 17 post-puberty obese adolescents, aged 15-19 years with body mass index (BMI) greater than >95th percentile of the CDC reference growth charts. Measurements of glucose metabolism,
inflammatory biomarkers, body composition and FGF-21 were performed. The adolescents were randomized in two different groups (Insulin Resistance = 8 and non-Insulin Resistance = 9) that were submitted
to an exercise training associated with clinical, nutritional and psychological counseling during one year. To statistical analysis it was adopted significant value of α ≤ 5%. The effects of therapy
was verified by ANOVA two way, post hoc Tukey to parametric data and Wilcoxon test was applied to non-parametric data. Correlations analyses were performed.

It was showed reduction in body mass in both groups. Only non-Insulin Resistance group was demonstrated improvement of body mass index, body fat mass, body lean mass, waist circumference; and
adiponectin/leptin ratio. In the Insulin Resistance group reduces in FGF-21 concentration and adiponectin/leptin ratio were observed. Positive correlation between FGF-21 with body lean mass; and
negative correlation between FGF-21/body fat mass ratio with waist circumference were showed. The insulin resistance prevalence reduces from 94% to 38.8% in the study sample.

According with our results it is possible to note that insulin resistance state is associated with a reduction in FGF-21 concentration in obese adolescents during weight loss process, favoring the
vicious cycle between obesity and inflammation. However, exercise associated with clinical approach can improve both metabolic and inflammatory state.

Funding: FAPESP (2013/041364; 2013/19046-0; 2013/08522-6; 2015/14309-9), CNPq (573587/2008-6; 300654/2013-8; 150177/2014-3) and CAPES.

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