Background: Sleep disruption and deprivation are common in contemporary society and have been linked with poor health and wellbeing. In contrast, the physical exercise has been
stimulated for general population with the aim of improving health and quality of life. However, the metabolic consequences of physical exercise in chronically restricted sleeping subjects are
unknown. Thus the objective of present study was evaluated if the physical exercise could interfere in the deleterious effects of sleep restriction considering metabolic and immunological parameters.
Methods: Eleven male subjects underwent test of performance maximum at voluntary exhaustion in 80% of ventilatory threshold 2 (VL2) in two conditions, as follow: - condition of sleep
habitual-SH (± 8 hours of sleep); and sleep restriction-SR (only 4 hours of sleep) for 3 nights (permitted to sleep between 01:00 and 05:00 h). Exhaustion time, heart rate and Borg scale were
evaluated. Moreover, in both conditions blood was collected before exercise, after the completion of exercise, and 1 h after recovery. Glucose, insulin, lipid profile (triglycerides, cholesterol, LDL,
HDL and VLDL), catecholamines (epinephrine and norepinephrine), testosterone, cortisol, GH, IL-1, IL-10, IL-6 and TNF-α were measured in serum or plasma.
Results: The sleep of volunteers was reduced by approximately 50% and there were no differences in parameters related to body composition. No differences were observed in performance
data after sleep restriction. Although they showed no significant differences in fasting glucose, a tendency of increase above the normal glucose values was observed after the RS and, the acute
physical exercise was effective in lowering these levels similar to SH condition. Moreover, there is an increase of ~40% in insulin and HOMA-IR and a decrease of ~40% in adiponectin levels reinforcing
an impact on glucose metabolism. Interestingly, we observed a decrease of triglycerides and VLDL-cholesterol after RS, which remained lower after completion of the physical exercise. No other
hormones or cytokines changes were observed.
Conclusions: Accordingly, these data indicate that even in sleep loss condition, the physical exercise must be stimulated for the specific population studied, since it was seen an
improvement of glucose metabolism without impairing other parameters.
Financial support: FAPESP, CNPq, CAPES and AFIP.