Background: The resistance training (REx) and chronic supraphysiological use of anabolic androgenic steroids (AAS) change neuroendocrine responses but the mechanisms involved are
unclear. Our aim was to evaluate the effects of nandrolone decanoate (DECA) associated to REx on central and peripheral hormones and neuropeptides related to the energetic balance.
Methods: The training protocol consisted of high intensity progressive resistance training in ladder for five days per week and the experimental protocol was performed for 8 week. A
total of 40 Wistar rats were distributed in 4 groups: C group: exposed to vehicle 3x/wk; T group, REx 5x/wk and vehicle 3x/wk; D group, exposed to DECA (s.a. 5mg/kg) 3x/wk; TD group, submitted to REx
5x/wk and DECA (s.a. 5mg/kg) 3x/wk.
Results: Efficiency training was confirmed by cross sectional area analysis of the gastrocnemius muscle, which was higher in T and TD groups than C and D groups. There was a reduction
of body weight in TD compared to C group and a reduction of total fat of T and TD groups compared to C group. We observed an increase of prepro-orexin mRNA expression in trained groups compared to C
group and the absence of changes in NPY, AGRP, POMC, CART, ghrelin receptor, leptin receptor, orexin-A receptor, AR and ER-α mRNA hypothalamic expression. There was an increase of leptin expression in
fat tissue in trained groups compared to C group. We also observed a reduction of leptin levels in D, T and TD groups compared to C group and increase of plasma orexin-A levels in D group compared to
C and T groups.
Conclusions: We found that resistance exercise plays a central and peripheral role on energy balance while, DECA changed only peripheral components.
This project was supported by: FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior), CNPq (Conselho Nacional de
Desenvolvimento Científico e Tecnológico) and AFIP (Associação Fundo de Incentivo à Pesquisa). VD’A is recipient of a fellowship from CNPq.