Background: Sleep deprivation is an increasingly common condition in modern society and has negative consequences for glucose metabolism, such as insulin resistance. To reverse or
minimize these effects, the practice of physical exercise is advised. In this scenario, the high intensity interval training (HIIT) emerges as an effective strategy in terms of volume/intensity and
time saving, bringing acute and chronic benefits for glucose homeostasis. Thus, the aim of this study was to investigate the effects of HIIT on glucose and insulin in healthy young after 24 hours of
total sleep deprivation.
Methods: Eleven young healthy, physically active, with regular eating habits and sleep duration 7-8 hours/night were recruited. The volunteers were submitted to Oral Glucose Tolerance
Test (OGTT) for 4 hours after a regular night's sleep (RS group) and after a night of sleep deprivation for 24 hours (SD group). Then the volunteers were submitted to HIIT for 2 weeks (6 training
sessions, 8 to 12 bouts at 100% maximal potency) on a cycle ergometer. After the last training session, volunteers were deprived of sleep for 24 hours and repeated the OGTT (HIIT + SD group). Before
and after the training period the volunteers performed two time-trial tests (4km and 30km). Shapiro Wilk's test was used to verify the normality, ANOVA two-way was used to compare the Area Under Curve
(AUC) of experimental conditions, and Student's t-test was used to compare pre- and post-training variables. The study was approved by Ethics Committee of UNIFESP (#522.163) and was registered in
Clinical Trials (NCT02125656).
Results: The AUC of glucose was 18% higher in SD group when compared to RS group (RS = 497.9 ± 78,5; SD = 587.5 ± 104.6; HIIT+SD = 547.7 ± 45.4) and the AUC of insulin was 61% higher
when compared to the others conditions (RS = 95.9 ± 52.6; SD = 153.1 ± 72.9; HIIT+SD = 102.7 ± 48.4). In the time-trial test 4km, post-training time was 6.68% lower when compared to pre-training (pre
= 299 ± 51.55 seconds; post = 279 ± 45.60 seconds). In the time-trial test 30km, post-training time was 11.92% lower when compared to pre-training (pre = 60.30 ± 11.13 minutes; post = 53.11 ± 5.89
Conclusions: HIIT for 2 weeks is a non-pharmacological strategy to minimize the negative impact of sleep deprivation on glucose metabolism, and is an efficient method to improve the
performance in healthy young.
Acknowledgments: AFIP, CAPES, CNPq and FAPESP.