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Abstract Details

Abstract Title

Neuroinflammatory response in aged rats submitted to strength training

Abstract Theme

Neuroscience and sport

Type Presentation

Poster

Abstract Authors

Presenter Erivelton Fernandes França - Universidade de Mogi das Cruzes (NPT) - BR
Fabrízio dos Santos Cardoso - Universidade de Mogi das Cruzes (NPT) - BR
Fernando Tadeu Serra - Universidade de Mogi das Cruzes (NPT) - BR
Alexandre Aparecido de Almeida - Universidade Federal de São Paulo (UNIFESP) (Departamento de Fisiologia) - BR
Pedro Luiz Garcia Braga - Universidade Federal de São Paulo (UNIFESP) (Programa de Pós-Graduação em Neurologia e Neurociências) - BR
Francisco Romero Cabral - Hospital Israelita Albert Einstein (Brain Institute) - BR
Miguel Luiz Batista Junior - Universidade de Mogi das Cruzes (NPT) - BR
Ricardo Mario Arida - Universidade Federal de São Paulo (UNIFESP) (Departamento de Fisiologia) - BR
Sérgio Gomes da Silva - Universidade de Mogi das Cruzes (NPT) - BR

Presentation Details

Poster Exhibition Site (Local): Orange - 8        Date: 1 September        Time: 8am to 7pm        Presenter: Erivelton França

Abstract Resume

Background: Aging is often accompanied by cognitive decline, memory impairment and an increased susceptibility to neurodegenerative disorders. Most of these age-related alterations
have been associated with deleterious processes such as neuroinflammation. Indeed, higher levels of pro-inflammatory cytokines and chemokines are found in the aged brain. This high pro-inflammatory
response represents one of the mechanisms that contribute to age-associated neuronal dysfunction and brain vulnerability. In this way, we conducted an experimental study to investigate whether a
strength exercise program could promote changes in inflammatory response in the brain of aged rats.

Methods: Twelve male rats Wistar (20 months of age) were randomly divided into two groups: strength training (ST; n=6) and control (CTL; n=6). The ST group was submitted to seven
weeks of strength training by climbing a ladder with load (from 50 to 75% of maximum load supported). Twenty-four hours after the last training session the blood and brain (cortical and hippocampal
regions) from CTL and ST groups were extracted to analyze the levels of cytokines and chemokines by Luminex MAGPIX system.

Results: The aged rats from ST group showed a significant decrease of serum levels of IL-13, IL-10 and TNFα and increase of levels of IL-18 compared to aged rats from CTL group. In
the brain cortex, reduced levels of MIP-1α, EGF, IL-18 and IP-10 were observed in aged animals from ST group compared to CTL group. In the hippocampus, strength training decreased the levels of IL-1a,
Rantes and increased the levels of G-CSF and IL-18.


Conclusions: The strength training is able to change the levels of cytokines and chemokines in the blood and in the brain of aged rats. Depending on the investigated structure (blood,
cortex and hippocampus), pro and/or anti-inflammatory effects were noted after training. However, in most cases, the strength training resulted in a beneficial anti-inflammatory response, mainly in
the hippocampal region.



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