Background:The aim is to explore the effects of rhodiola formulations on the release, absorption and utilization of its active ingredients by comparing the effects of nano rhodiola
and common rhodiola on the sports fatigue of rats.
Methods:36 SPF male rats aged 8 weeks were randomly divided into 3 groups(n=12), namely the nano rhodiola group(266.1nm), common rhodiola group and control group. The rats were
separately fed 0.5ml nano rhodiola solution(0.01mg/ml),common rhodiola solution(0.01mg/ml) and distilled water once a day. All rats were required to take moderate intensity treadmill training(refered
to Bedford's classical exercise load model) every day. 4 week later, all rats were forced to take exhaustive swimming and the duration were recorded. After exhaustive swimming, the plasmas, livers and
quadriceps were taken as samples to measure the activity of super oxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxygen capability (T-AOC) and malonaldehyde (MDA).
Results:The mean duration time of nano rhodiola group is longer than the common rhodiola group but without statistical significance; MDA in plasma of the nano rhodiola group is lower
than that of the control group (P<0.05); T-AOC activity in plasma of the nano rhodiola group is higher than that of the common rhodiola group, and T-AOC activity in plasma of both the nano and common
rhodiola groups are higher than that of the control group (P<0.05); SOD activity in quadriceps femoris of the Nano rhodiola group is higher than that of the common rhodiola group, and SOD activity in
quadriceps femoris of both the Nano and common rhodiola groups are higher than that of the control group (P< 0.05).
The rhodiola supplements improved the SOD activity in quadriceps femoris, the T-AOC activity in plasma, and reduced the MDA content in plasma of rats. The effects of nano rhodiola supplements on the
T-AOC activity, MDA content in plasma and the SOD activity in quadriceps femoris were more significant than that of common Rhodiola supplements, it suggested that the rhodiola particle size might be
one important factor which influence its effect on sports fatigue.