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Abstract Details

Abstract Title

The Effect of Ibuprofen on Rat's Skeletal Muscle Inflammation Process and Satellite Cell Proliferation after a Single Eccentric Exercise

Abstract Theme

Sport medicine and injury prevention

Type Presentation

Oral presentation

Abstract Authors

Presenter LeiAi - JIANGSU RESEARCH INSTITUTE OF SPORTS SCIENCE (The Second Scientific Research Center of Competitive Sports) - CN
LingLiu - JIANGSU RESEARCH INSTITUTE OF SPORTS SCIENCE (The Second Scientific Research Center of Competitive Sports) - CN
XiaoMeiZhu - JIANGSU RESEARCH INSTITUTE OF SPORTS SCIENCE (The Second Scientific Research Center of Competitive Sports) - CN
YueZhou - BEIJING SPORT UNIVERSITY (Department of Human Movement Science) - CN

Presentation Details

Room: Venus        Date: 1 September        Time: 11:00:00        Presenter: Lei Ai

Abstract Resume

Background:Muscle Damaged is so Common in Sports that every Professional Athlete may be Suffered from it. So many Athletes Taking NSAIDs(such as Ibuprofen) to Ease the Pain and
Accelerate the Recovery Process when They are Suffered from Injury in their Usual Training Period. But some Studies’ result Confused us that the use of NSAIDs may Inhibit the Proliferation of
Satellite Cell and Delay the Repair of Injured Muscle. Therefore, the Aim of this Study is to Observe the Size of Inflammatory Response Impact on the Plasma Inflammatory Factor TNFα and IL-6, as well
as its Effect on the Satellite Cell Proliferation and Differentiation. Provide Theoretical Support to how can We Shorten the Period of Inflammatory Response and Speed up the Muscle Regeneration after
Injury, then Guiding Athletes to Treat Muscle Damage .


Methods: Sixty-Six Male SD Rats were Randomly Divided into Four Groups: Quiet and Lavage Physiological Saline Group(CS), Excise and Lavage Physiological Saline Group (ES), Quiet and
Lavage Ibuprofen Group (CI), Excise and Lavage Ibuprofen Group (EI). Rats of Group ES and EI were Submitted to Eccentric Exercise at a Speed about 20土1m/min on a Treadmill which set at down 16°
Decline for Ninety Minutes. All of the Arts were Hocussed by Inject 3% of Sodium Pentobarbital into its Celiac, Then Centrifuged the Blood of Abdominal Aortic to get Plasma for Test the Level of IL-6
and TNFα, and took the Rat’s Plantaris (Fast-Twitch) and Soleus (Slow-Twitch) Apply for Measure the Expression of Myod and M-Cadherin in Muscle.


Results:(1) All Rats’ Plasma IL-6 Level were Significantly Increased Compare with Quiet Group after the First, the Fifth, and the Seventh Day (P<0.05), but its not Reached Significant
Level in the Second Day. (2)All Exercised Rats' Plasma TNFα Level were Significantly Increase Compare with Quiet Group after the First and the Second Day (P<0.05), only the Group of ES in the Fifth
day Reached Significant Level in the Rest Groups. (3) The Expression of Muscle Myod Increased Significantly in Group EI Compare with Group CI in the Frist day(P<0.05), but all Groups’ Expression of
Muscle M-Cad didn’t appear Significant Change at the same time. Almost all Exercise Groups’ Expression of Muscle Myod were Increase Significantly Compare with Control Group in the Second and the Fifth
Day, but only Group EI’s Expression of Muscle M-Cad were Raised Significantly Compare with Group CI (P < 0.05). The Group ES’s Expression of Muscle Myod and M-Cad almost all Raised Significantly
Compare with Group CS (P<0.05), but the Group EI Appeared to Down-Regulated Expression of Muscle Myod and M-Cad at the same time.


Conclusions:(1) There may be exist Antagonism Effect between Plasma IL-6 with TNFα, and Plasma IL-6 may relate to the Regeneration of Damaged Muscle Fiber. (2) Satellite Cells begin
to Proliferate in the First Day after Exercise, and Activated Satellite Cell Entered into the Peak Value of Differentiation in about Fife to Seven Days after Exercise. (3) A Certain amount of
Inflammation Cells may be Beneficial for the Proliferation of Satellite Cell.


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