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Abstract Details

Abstract Title

Increase in Cardiorespiratory Fitness Improves Inflammatory Status in Obese Women

Abstract Theme

Physical activity and health

Type Presentation

Oral presentation

Abstract Authors

Presenter Ricardo Badan Sanches - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
Stephan Garcia Andrade Silva - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
João Pedro Novo Fidalgo - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
Leticia Andrade Cerrone - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
Maythe Amaral Nascimento - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
Renata Astride Rebelo - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
Vanessa F. Schoenardie Poli - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Interdisciplinary Health Sciences, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
Paula Bresciani Leite - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Post Graduate Program of Nutrition, Federal University of São Paulo – UNIFESP - Santos, Brazil.) - BR
Liu Chiao Yi - Federal University of São Paulo – UNIFESP - Santos, Brazil. (Department Sciences of Human Movement, Federal University of São Paulo – UNIFESP - Santos, Brazil) - BR
Ronaldo Vagner Thomatieli dos Santos - Federal University of São Paulo – UNIFESP - Santos, Brazil. (Department of Biosciences, Federal University of São Paulo – UNIFESP - Santos, Brazil) - BR
Danielle Arisa Caranti - Obesity Study Group (GEO), Federal University of São Paulo – UNIFESP - Santos, Brazil. (Department of Biosciences, Federal University of São Paulo – UNIFESP - Santos, Brazil) - BR

Presentation Details

Room: Terra        Date: 4 September        Time: 10:20:00        Presenter: Ricardo Sanches

Abstract Resume

Background: Obesity is associated with an imbalance in cytokine concentrations and therefore low-grade chronic inflammatory status. The cardiorespiratory fitness (CRF) is an important
parameter that can influence the inflammatory status, being a powerful predictor of early mortality independent of physical activity levels, body mass index, or other risk factors. In this way, the
aim of this study was to analyze if the increase in cardiorespiratory fitness can improve some pro and anti-inflammatory proteins in obese women after an interdisciplinary therapy.

Methods: A total of 20 obese women (41.8±6.4 years old and BMI 34.5±3.2 kg/m²) performed 32 weeks of interdisciplinary therapy (IT). The therapy was composed by physical exercise 3
times per week, and physiotherapy, nutrition and psychology, once a week, 60 min per session. The CRF was determined by maximum oxygen uptake (VO2max.) using a maximum cardiopulmonary exercise test.
The plasma levels of leptin and IL-10 were determined by ELISA immunoassay. All measures were carried out at baseline and after the IT. In statistics analysis were used the percentage difference
between pre and post therapy (Δ%) and it were performed a Pearson’s correlation test (p<0.05).

Results: After the IT was found an important correlation between Δ% of VO2max. and Δ% of IL-10 level (anti-inflammatory) (r=0.69, p=0.001); and an inverse correlation between Δ% of
VO2max. and Δ% of plasma leptin (pro-inflammatory) (r=-0.58, p=0.007).

Conclusions: The improvement on CRF was associated with an increase of plasma IL-10 level and in reduction of plasma leptin level. Our results show that the more the CRF was increased
more the inflammatory status was improved. In this way, the interdisciplinary therapy can be a good strategy to treat obesity and its comorbidities.

Funding: Research relating to this abstract was funded by FAPESP 2015/00953-3 and CNPq.


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