Severe obese adults were recruited for a 16-week exercise to lose weight, so as to observe obese subjects’ blood fatty acid composition, lipids, insulin, leptin, adiponectin and lipoprteinlipase
during the long term aerobic exercise intervention and discussed the effects of aerobic exercise on lipid metabolism.
12 severe obese adults aged of 22.17±4.78 were selected from the fully closed weight loss camp in Shanghai. Before intervention, the subjects were provided the exercise prescriptions based on their
health and exercise capacity. Heart rate (HR) was chose to monitor the exercise intensity. Target HR= resting HR+ HR reserve×（20%～40%）. The exercise program was easy control and long duration such as
swimming, fast walking, jogging, aerobics, etc. According to the working out energy requirement based on the age, weight and BMR, professional dieticians offered reasonable daily calories and
nutrition. The subjects were taken fasting blood tests and measured body morphology index before intervention and the last morning of 4th,8th,12th,16th weeks intervention in order to observe the
changes of body shape, lipids, insulin, insulin, leptin, adiponectin, lipoprteinlipase and blood fatty acid composition.
After 16 weeks, the subjects’ body weight, body fat percent, waistline, hip circumference, waist hip ratio all dropped significantly. At the 8th and 16th week, serum TFA, UFA, MUFA, PUFA, n-6 PUFA,
n-3 PUFA declined significantly; Serum palmitic,γ-linolenic, palitoleic, oleic, linoleic,α-linolenic dropped after the intervention At the 8th week, stearic did not change significantly, but had a
declined significantly at the 16th week; DHA dropped significantly at the end of the 8th week; Oleic/TFA dropped at the 8th week, palmitic/TFA rose at the end of 16th week but at that time
α-linolenic/TFA, γ-linolenic/TFA dropped significantly. 16 weeks later, subjects’ Serum triglyceride, total cholesterol, LDL-C and fasting plasma glucose dropped. Compared with levels before
intervention, HDL-C/LDL-C rose at the end of the 8th, 12th and 16th weeks. Insulin and HOMA-IR dropped at the end of the 8th, 12th and 16th weeks, and had significant statistical significances. Leptin
declined gradually, and had significant statistical significance at the end of the 8th and 12th weeks. The insulin level in the 16th week dropped very significantly, but Adiponectin and
lipoprteinlipase rose gradually after intervention.
Long term aerobic exercise intervention would significantly bring down obese subjects’ body weight, body fat percent, BMI, fat mass and improve their body shape;Severe obese subjects have emerged the
lipid metabolism disorder and insulin resistance. 16 weeks aerobic exercise could improve their blood lipids and insulin, and bring down their serum fatty acid compositon and leptin, which would
improve their fasting serum lipoprotein lipase activity. It played an important role in improving lipid metabolism and promoting health in obese adults.