Background:The survey showed that about 60 percent of American people have some mood disorders and suicide attempts, and the annual number of suicides has risen to 10 million in the
world. More importantly, a large part of the patients with severe depression will show a noticeable anger / aggressive. WHO (World Health Organization) reported that about 143 million people worldwide
die from suicide or violence between people (not including the armed combat)in a year, and most is non-fatal violence. Previous studies have confirmed: moderate-intensity aerobic exercise can
effectively mitigate attacks in rats. In this study, swimming is used as a means of intervention, to explore the effect of swimming in the expression of PGC-1α, FNDC5 ,BDNF in aggressive behavior rat
Methods:8-week-old rats were randomly divided into five groups: C (Control) (8), T (Tested) (10), E (Exercise) (12), TE (Tested + Exercise) (12), A (Attack) (8).Using live - intrusion
of modeling, carried out four weeks swimming training three weeks later.
Detection indicators and methods: Western blot were used to detect the expression of hippocampal BDNF, PGC-1α, FNDC5, RT-PCR to detect the expression of BDNFmRNA, PGC-1αmRNA, FNDC5mRNA in hippocampal
Results:(1)The results of space exploration experimental: The group T VS group E, the percentage of the total distance there was a significant difference (P <0.05).The target quadrant
time of group E compared with the group T showed a significant difference (P<0.05). Four groups of cross platform number did not appear differences.
(2)Paired samples T-test to test indicators of water maze after modeling and exercise: there was a significant difference in four groups(P<0.01)between before and after exercise in 4 days positioning
heading experiment incubation period. There was a significant difference in four groups between before and after exercise in space exploration experiment(P <0.01).
(3)Western Blot analysis showed: after four weeks swimming, there were differences in the expression of hippocampus PGC-1α between group C, group T and two swimming groups, respectively, compared to
the group E(P<0.05) and group TE(P<0.01).Swimming can raised the expression of FNDC5 in hippocampus, there was a difference between group C and group TE and group T (P<0.05).The expression of BDNF in
hippocampus, there was differences between group E and group C(P<0.01),and a differences between group E and group T (P<0.05). The group TE compared with the group C, there was a significant
difference (P<0.01), there was a significant difference (P<0.05) compared with the model group T.
(4)Four weeks’ swimming can improve the expression of PGC-1αmRNA, FNDC5mRNA and BDNFmRNA,and there is a significant correlation (P <0.01) in the expression of BDNFmRNA and FNDC5mRNA.
Conclusions:(1)4 weeks’ swimming training can improve the aggressive behavior rats in exploring the surrounding environment and the attention to themselves,change the state of
excitement and fears in rats.
(2)Four weeks after modeling, Rats without intrusion stimulation could make the expression of hippocampal BDNF levels returned to normal levels.But long-term solitary