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Abstract Details

Abstract Title

Exercise-induced Autophagy is a Beneficial Promoter for Health

Abstract Theme

Physical activity and health

Type Presentation

Oral presentation

Abstract Authors

Presenter Ning Chen - Wuhan Sports University (Hubei Exercise Training and Monitoring Key Laboratory, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science) - CN
Jingjing Fan - Wuhan Sports University (Hubei Exercise Training and Monitoring Key Laboratory, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science) - CN
Shaohui Jia - Wuhan Sports University (Hubei Exercise Training and Monitoring Key Laboratory, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science) - CN
Xuanjuan Kou - Wuhan Sports University (Hubei Exercise Training and Monitoring Key Laboratory, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science) - CN
Yi Yang - Wuhan Sports University (Hubei Exercise Training and Monitoring Key Laboratory, Hubei Provincial Collaborative Innovation Center for Exercise and Health Promotion, College of Health Science) - CN
Qingxue Li - Wuhan Sports University (Graduate School ) - CN
Xiaoqi Yang - Wuhan Sports University (Graduate School) - CN
Ziyang Shu - Wuhan Sports University (Graduate School) - CN

Presentation Details

Room: Marte        Date: 4 September        Time: 18:00:00        Presenter: Ning Chen

Abstract Resume

Background: It is well known that Exercise is Medicine. Currently, exercise-induced autophagy for health promotion has gained tremendous attentions in the field of exercise
physiology. Autophagy is an evolutionarily conserved process involving the degradation of cellular components in lysosomes to maintain cellular homeostasis and quality control, as well as temporarily
sustain cell viability in response to stressful stimuli. Since activated autophagy can execute the clearance of senescent cells or organelles, and provide a stable homeostasis and high-quality life
for the survival of normal cells, exercise-induced autophagy should have the potential for preventing and treating chronic diseases, delaying aging process, or extending longevity.

Methods: In our research group, we have established a series of rat models with chronic diseases including diabetes or sarcopenia. These model rats were subjected to exercise
intervention such as treadmill running, swimming, volunteer wheeling running, resistance training, or combinatorial training. The efficacy of exercise invention for these chronic diseases was
evaluated and corresponding signal pathways associated with autophagy or mitophagy after exercise interventions were explored through Western blotting, RT-PCR, transmission electronic microscopy and
RNA-seq or microRNA analysis.

Results: Appropriate exercise is an autophagy or mitophagy enhancer to regulate cellular homeostasis, improve mitochondrial quality control and mitigate metabolic stress.
Exercise-induced autophagy can enhance insulin sensitivity and improve glucose consumption, thereby realizing the prevention and synergistic treatment of diabetes. Meanwhile, exercise-induced
autophagy and irisin may also mutually promote the regulation of diabetes. In addition, due to the dysfunctional autophagy during sarcopenia, appropriate exercise training can execute the activation
of autophagy to modulate the quality control of mitochondria through PGC-1α-AMPK-FOXO3 signal axis, correspondingly mitigating the occurrence of sarcopenia.

Conclusions: These studies provide useful information on how to use the functional status of autophagy to improve the efficacy of the prevention and treatments for these diseases, and
insight how to take advantage of autophagic regulation to achieve health-promoting roles, which will produce medical significance and social benefits for health promotion.

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